British Air Force Typhoon jets have operated alongside France's air force in a coordinated attack against an hidden munitions depot in Syria employed by the IS group, according to the UK Ministry of Defence.
The site, identified by reconnaissance, was believed to be housing weapons and explosive materials, the statement said, and was situated in mountains just to the north of Palmyra in Syria's central region.
"The RAF jets used precision-guided Paveway IV munitions to strike a several access tunnels providing entry to the facility... preliminary assessments suggest the objective was successfully hit," officials stated.
There was no evidence of any civilian casualties in the operation on Saturday evening and every plane involved returned safely, the MoD added.
The British jets were assisted by a Voyager aerial refuelling aircraft.
Daesh - also known as ISIS - imposed jihadist rule over parts of Syria and Iraq prior to its 2019 collapse.
"This strike shows British leadership, and resolve to work closely with our partners, to eradicate any re-emergence of the terrorist group and their harmful and extremist ideologies in the area," the British Defence Secretary the minister remarked.
RAF aircraft have performed patrols over Syrian airspace to "prevent any attempted comeback" of IS after its defeat at the battle of Baghuz in the year 2019, the MoD reported.
"I want to thank the personnel of our armed forces who took part in this mission for their skill and their valour," Healey commented. "Including them were numerous British troops stationed over Christmas and New Year. This mission, to remove dangerous terrorists who endanger our way of life, shows how UK forces are always on standby, all year round, ensuring Britain's security at home and influential overseas."
In December, the United States armed forces carried out what it called a "large-scale strike" against IS targets in the country, following an assault claimed the lives of two American soldiers and a civilian interpreter in Palmyra.
The UN says Islamic State still has between 5,000 and 7,000 fighters in Syria and Iraq.